Lone Wolf and Cub is a fictional story where some real historic events are included. The main characters Ogami Itto and his son Daigoro (fictional character) are falsely accused against the Tokugawa Shogun by the Yagyu clan (one of the most powerful clans during the Edo era, that existed in reality). From that moment and on Ogami and his son will seek revenge against the Yagyu.
Ogami Itto and his son.
Half of the Lone Wolf and Cub Japanese volumes owned by my friend Yamamoto. The whole series is composed of 28 volumes.
Ogami Itto fighting against Retsudo Yubei (one of the legendary Yagyu Yubei brothers).
The manga was a great success in Japan and many movies and TV series where created based on it. Quentin Tarantino saw one of the movies (Shogun Assassin) and became a fan of Lone Wolf and Cub, he read the manga, saw the television series, movies, etc. He used all that inspiration to create Kill Bill. In fact, at the end of Kill Bill Vol.2 the main character and ******* (Kill Bill Spoiler warning) are watching Shogun Assassin laying on a bed.
And not only it has influenced Tarantino, many other samurai movies are inspired in certain way by Lone Wolf and Cub, Final Fantasy video games have subtle references to the manga; and also Rurouni Kenshin anime, the movie Sin City and even The Ninja Turtles have been influenced by Lone Wolf and Cub. For a complete list of works influenced by Lone Wolf and Cub nothing better than Wikipedia.
The TV series soundtrack.